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SOLO™ Automated Liquid Handler

Overview
Description
Specifications
Applications
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A High Resolution, Compact Robotic Pipettor offering Flexibility and Precision

The Hudson SOLO™ Liquid Handler is an innovative automated pipettor designed to streamline liquid handling processes in research, pharmaceutical, and clinical laboratories. With its small footprint, flexibility, and user-friendly interface, the SOLO liquid handler offers unparalleled convenience and efficiency in pipetting tasks.
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SOLO™ Automated Liquid Handler

Description

Available in single, 8-, and 12-channel configurations, the SOLO™ Automated Liquid Handler is a flexible automated pipetting system built around industry-standard pipette technology, integrated with Hudson’s precision motor drive for improved consistency and throughput.

SOLO delivers reliable performance within the specified operating range of the pipette, with validated accuracy and precision aligned to ISO 8655 standards. For a 20–200 µL pipette, performance is specified at ≥20 µL, ensuring robust and reproducible liquid handling. Typical precision is ≤1% CV depending on volume and liquid characteristics, with higher volumes delivering improved consistency.

The SOLO™ Automated Liquid Handler is:

  • Intuitive, it only takes minutes to learn to use
  • Easy-to-use, agile, and flexible SOLOSoft™ software for data tracking and scheduling
  • Precise as any ‘big deck’ robotic liquid handling system
  • Compact footprint utilizes less bench space and easily fits on lab benchtops and into many standard fume hoods and biosafety cabinets
  • Walk-away freedom from a continuous unattended operating system
  • Available with a single channel, or multichannel (n 8-tip or 12-tip) pipette head and comes with a 6-12 position deck
  • Deck can be extended to the left or right side for integrating other instruments
  • Gripper available for moving labware around the deck.
  • Can easily be integrated with additional instruments and software at any time
  • Easily customized for unique or specialized applications

Users who wish to cherry-pick from individual wells can use either the single-tip SOLO (as shown in the video clip below) or the multi-tip configuration by picking up a single tip at a time.  The SOLO 8-channel pipet head can work with just one tip, several tips, or all 8 tips without any issues. There is no need to switch to a single tip pipette head.

The SOLO multi-tip offers a broad pipetting range. The mechanical drive and software controls of the pipette head allow the SOLO to push the boundaries of pipetting performance & liquid handling.

Specifications

Dispensing Single channel – 1ul to 10 ml; optional pump assembly for bulk dispensing. 8 & 12 channel : 1-10 ul pipette head; 5 – 200ul pipette head; 20 – 1000 ul pipette head.
Volume Broad volume range: to 1000ul for the multi-tip heads, to 10mL for the single-tip heads.
Plate Capacity 4, 6, 8, 10,12 microplate positions available.
Optional Microplate Gripper Move plates to accessories on the deck or other instruments with the left hand or right-hand extension options.
Plate Format SBS standard footprint, any well configuration; inquire about custom nests.  8-, 24-, 96-, 384- and 1536-well microplate compatible.
Tubes, Flasks, and Vials Any SLAS/ANSI compatible formats
Housing material  Stainless main deck; painted steel upper arm covers over machined aluminum structural components.
Spill Protection All electronics protected by solid, non-penetrated cover to prevent any leakage onto electrical devices
Arm Mechanism Horizontal Travel/Vertical Stroke: x=22.5″; y=9.3″; z=4.0″
Size As small as 24.0″ x 29.5″ x 19.5″ (H x W x D) for a 4-microplate position SOLO
Weight 50lbs
Upgrades LabLinx™ upgrade available anytime for unparalleled flexibility and high throughput.
Power Requirements 120-240 VAC, 50-60Hz, 2Amps Max at 120
Computer Interface RS-232 serial cable
Precision The SOLO™ pipetting system leverages a high-resolution motor drive combined with calibrated pipette technology to deliver consistent and reproducible liquid handling.

Performance is dependent on volume, liquid properties, and pipetting technique, and is specified within the validated operating range of the pipette. For a 20–200 µL pipette, recommended operating volumes begin at 20 µL (10% of nominal volume), in line with ISO 8655 standards.

Within this range:

Precision:
typically ≤1.5% CV at lower volumes, improving to ≤0.6% CV at higher volumes

Accuracy:
typically ±1–3%, depending on volume

For applications requiring lower volumes, SOLO can be configured with alternative pipette ranges to maintain performance and reproducibility.

Speed
Below are some timing results based on filling each well of a 96 well plate with 5uL of liquid, one well at a time.

Method Average Time/ Plate (min:sec)
Aspirate from a reservoir (Same point each time) 1:43
Copy plate – well by well with no tip changes 6:18
Copy plate – well by well with 96 tip changes 29:04

Applications

The SOLO Liquid Handler was developed to meet the growing need throughout the research, pharmaceutical and clinical communities for a high-resolution, compact robotic pipettor. It can be adapted to any research activity which requires the accurate addition, removal, and mixing of liquid samples and reagents – including those containing live cells. The SOLO can be integrated with other automated instruments for seamless process control and flexibility.

Applications include:

DNA Extraction
Microbiome/Microbiota Research
Oligo Pooling
Oligo Purification
Gene Assembly
DNA and RNA Normalization
Synthetic Biology
Plasmid Preparation
Fungal, Yeast, Bacterial Colony Picking
Colony Plating
DNA Transformation into Bacteria
Protein Binding
Protein Expression & Purification
Handling Non-Standard Sample Plates
ELISA
Serial Dilutions

Documents & Videos

SOLO Robotic Pipettor Product Sheet

Accessories

 

PlateCrane EX Robot Arm

  • Easy integration using SoftLinx
  • Up to 15 stacks, 450 plate capacity
  • Easy combination with SoloSoft™ methods
  • Access to any SOLO plate nest
LabLinx Microplate Stacker

  • Feeds plates on track mounted directly to SOLO deck
  • Up to 4 Stackers per SOLO, 480 microplate capacity
  • Easy integration using SoftLinx
  • Multiple plates handled simultaneously
  • Easy combination with SoloSoft methods
  • Access to any SOLO plate nest
Micro10x Reagent Dispenser

  • Fast, accurate dispensing of bulk reagents
  • 8- or 12-channel dispense manifolds
  • Portrait or Landscape orientation
  • Mounts to SOLO as a plate nest position
  • Easily integrates into SoloSoft pipetting methods
  • Dramatically increases SOLO throughput
Magnetic Bead Station

  • Computer controlled magnetic bead separation methods
  • NdFeB neodymium Magnets
  • 24, 96, and 384 well Ring Magnets available
FilterPress Pressure Filtration Station

  • Dispense samples and solvents directly into filter plates
  • Computer control of pressure ramp-up/down
  • Detects and reports actual pressure level
  • Easy integration using SoftLinx
  • Mounts to SOLO as a plate nest position
Heating/Cooling Nest

  • Electrical: 100 – 260 VAC; 50-60 Hz; 0.5W
  • RS-232 interface through SoloSoft
  • Temp. Range: -10°C to 100°C
  • Logs actual nest temperature during run
  • Easy integration into SoloSoft pipetting methods
  • Flexible user options:
Shaker Nest

  • Electrical: 115 – 230 VAC; 50-60 Hz; 3W
  • RS-232 interface through SoloSoft
  • Shaking Speed: 100 to 2000RPM
  • Up to 4 independently-controlled shaker nests per SOLO
  • Easy integration into SoloSoft pipetting methods
  • Control of Shake Speed, Shake Time, Acceleration and Shaking Pattern

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