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Rapid pH Plus Automated pH Meter

Precise, reliable plate handling across your entire workflow

Replace hours of manual pH measurement with minutes of setup and automated plate-based workflows. Set up your plate, press start, and walk away.

Rapid pH Plus is an automated, plate-based system powered by intuitive software that enables reproducible, searchable data generation for high-throughput formulation and buffer optimization workflows.

Configurable hardware supports single- or 4-probe capacity, with optional Power Wash, enabling scalable performance across diverse biologics development workflows

Rapid Ph Plus Software

Explore the software that unifies drug product development workflows across projects and timescales with fast, intuitive control.

Rapid pH Plus Software provides complete configurability across plate, workflow, and data settings for reproducible results at scale.

Purpose-built for scalable biologics development

Integrated platform for reliable plate-based pH measurement workflows

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Applications

Model Best For Thoughput
(full 96-well plate)
Sample
Complexity
Key
Application Fit

Rapid pH Plus
Single-Probe

Routine workflows, smaller studies, QC testing
~1.5 hours
Standard samples (buffers, simple formulations)
General pH measurement, medium throughput screening

Rapid pH Plus
Single-Probe + Power Wash

Workflows with difficult or carryover-prone samples
~1.5 hours
Viscous, protein-rich, or residue-forming samples
Formulation work with challenging matrices requiring enhanced cleaning

Rapid pH Plus
4-Probe

High-throughput workflows
~20-25 mins
Standard samples across many conditions
Large-scale buffer optimization and plate-based screening

Rapid pH Plus 
4-Probe + Power Wash

High-throughput workflows with difficult or carryover-prone samples
~20-25 mins
Viscous, sticky, surfactant-rich, or complex samples
Scalable formulation and buffer optimization with difficult sample types

What's Included

The Rapid pH Plus line shares core hardware and software capabilities but is tunable to the speed and washing needs of your workflow.
Model Mettler Toledo InLab® Micro Probe Power Wash Heated Nest Integrated Wash System Laptop + Rapid pH Plus Software Barcode Integration

Rapid pH Plus
Single-Probe

Single
Optional
(API or file-based integration)

Rapid pH Plus
Single-Probe + Power Wash

Single
Optional
(API or file-based integration)

Rapid pH Plus
4-Probe

4
Optional
(API or file-based integration)

Rapid pH Plus 
4-Probe + Power Wash

4
Optional
(API or file-based integration)

Specifications

Category Parameter Specification
Plate ConfigurationPlate FormatsSupports standard 96-, 48-, and 24-well plates and other ANSI/SLAS-compatible plate formats for probe-based measurement
Rows and ColumnsFully customizable plate layouts
Well SpacingConfigurable X/Y spacing (mm)
A1 OffsetAdjustable X/Y offsets for custom plates
Plate HeightUser-defined (max ~52 mm)
Read DepthAdjustable probe depth per plate
Wash and Cleaning Configuration Wash Methods Fully customizable multi-step workflows
Wash Steps Wash, dry, wait, buffer soak
Step Order Drag-and-drop reordering
Cycle Wash Configurable as a step (not fixed)
Dry Cycles Adjustable number of air-dry cycles
Multiple Methods Support for multiple saved wash protocols
Probe and Measurement Configuration Probe Type Mettler Toledo InLab® Micro Probe
Probe Configurations Available in single- and 4-probe systems (software supports scalable multi-probe configurations)
Multi-Read Configurable number of reads per well
Read Averaging Automatic averaging of multiple reads
Read Order Row forward/reverse, column forward/reverse
Sample Temperature User-defined estimate
Heated Nest Control Adjustable target temperature
Workflow and Run ConfigurationWell SelectionClick, drag, row, column, or full plate
Minimum Sample Volume~200 µL (typical for 96-well plates)
Sample SelectionManual selection or file-based (CSV) import
Sample ID IntegrationCSV-based mapping per well
Barcode IntegrationExternal (via API or file-based integration)
Notes & MetadataUser-defined searchable run notes and keywords
Run ControlStart, pause, stop
Collision DetectionSensor-based protection to prevent probe damage
Throughput~1.5 hours per 96-well plate (single-probe)<BR>
~20-25 minutes per 96-well plate (4-probe)
Data and Export Configuration Export Formats XML, CSV, SAM, Excel, JSON
Export Mode Plate layout, list, read-order
Auto Export Configurable export folder
Multi-Plate Export Batch export capabilities
Clipboard Export Copy data directly for external use
Data Capture Stores individual read values with automatic calculation of mean and standard deviation
Calibration and Tolerance Configuration Calibration Points User-defined (supports any standard buffer; common examples include pH 4,7,10)
Verification Wells Optional
Offset Tolerance Configurable (default ±50 mV)
Slope Tolerance Configurable (default ±5%)
Slope Deviation Configurable (default 5%)
Verification Tolerance Configurable (default ±0.05 pH)
Multi-Read Tolerance Configurable

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